منابع مشابه
Pharmacological studies on a locust neuromuscular preparation.
1. The structure-activity relationships of agonists of the locust excitatory neuromuscular synapse have been reinvestigated, paying particular attention to the purity of compounds, and to the characteristics and repeatability of the muscle response. The concentrations of compounds required to stimulate contractions of the retractor unguis muscle equal in force to the neurally evoked contraction...
متن کاملThe effects of myomodulin and structurally related neuropeptides on skeletal neuromuscular transmission in the locust.
1. The modulatory actions of myomodulin A on tension generated in the extensortibiae muscle of the locust hindleg by stimulation of the slow excitatory motoneurone (SETi) depend upon the frequency of stimulation. Myomodulin A has no consistent effect on the tension induced by the fast extensor motoneurone (FETi) or upon the myogenic rhythm present in the extensor. The effects of a range of stru...
متن کاملEffects of dineopentyl and dipinacoline ethers of glutamic acid on neuromuscular transmission in locust (Locusta migratoria).
The problem of the relationship between structure of dicarboxylic acid derivatives and their capacity to act on glutamate receptors has been extensively studied in various animal species (Piggot et al. 1975; Walker and James 1980; Puil 1981; Mandelshtam 1983). A number of substances with anticonvulsive properties (Meldrum et al. 1983; Colton and Colton 1985) and other preparations with pharmaco...
متن کاملEffect of denervation on neuromuscular transmission and glutamate sensitivity of the locust wing muscle fibers.
Changes in neuromuscular transmission and ultrastructure of synapses taking place after motor nerve cutting during 20 subsequent days were studied on the wing muscle of the locust (muscle 120) using intracellular recording from phasic fibres. The membrane potential (MP) and the excitatory postsynaptic potential (EPSP) showed practically no changes in comparison with the controls through day 8 a...
متن کاملNeuromuscular transmission in Peripatus.
The electrical and mechanical responses of body, leg and jaw muscle of Peripatus to electrical excitation of their motor-nerves were examined. A small twitch was obtained from each muscle, whose strength increased stepwise with increasing stimulus strength. In jaw and body muscles as many as ten increments in height were obtained with increasing stimulus strength. Only a single twitch height wa...
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ژورنال
عنوان ژورنال: The Journal of Physiology
سال: 1953
ISSN: 0022-3751
DOI: 10.1113/jphysiol.1953.sp004963